Top 10 Compounds for Metabolic Health & Longevity

The #1 choice for metabolic reset. 15-21% body weight reduction, improved insulin sensitivity, reduced liver fat, cardioprotective effects. Now preferred over semaglutide by most longevity MDs.

Best value longevity compound. Nature 2023 study showed lifespan extension. Reduces inflammation, improves mitochondrial function, helps NAFLD, supports glucose control. Safe and foundational - stack with creatine.

Increases muscle and brain ATP, reduces sarcopenia, improves glucose disposal, provides neuroprotection, reduces fatigue. Works even in sedentary/older adults - not just for athletes. 1000+ human studies with decades of safety data.

Gold standard for metabolic longevity. Activates AMPK, reduces mTOR overactivation, lowers insulin/IGF-1, reduces cancer risk, potential lifespan extension (TAME trial ongoing). Best with B12 monitoring.

Boosts NAD+, activates sirtuins (SIRT1/3), enhances mitochondrial biogenesis, improves vascular health. NR (Niagen) preferred for regulatory confidence. NMN catching up with more research.

Leading mitochondrial peptide. Exercise-mimetic that improves insulin sensitivity, increases muscle glucose uptake, reduces age-related metabolic decline. Best taken post-workout or AM.

Reduces triglycerides, decreases inflammation (resolvins), improves membrane fluidity, cardioprotective, supports brain aging. Use re-esterified triglyceride (rTG) form for best absorption.

Cofactor for 300+ enzymes including ATP and DNA repair. Reduces insulin resistance, supports sleep and stress resilience. Glycinate for relaxation, L-Threonate for brain. Avoid oxide form.

AMPK activator like metformin. Reduces fasting glucose, lowers LDL, increases GLP-1, antimicrobial gut benefits. Great metformin alternative or adjunct. Note: may interact with meds (CYP3A4).

Immune modulation, reduces inflammation, supports calcium metabolism. K2 directs calcium to bones, not arteries. Test 25(OH)D first - aim for 40-60 ng/mL.