What Does 109% Mean?

109%

The mice lived more than TWICE as long as expected. Here's what that means in human terms.

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The Actual Mouse Study

Starting Age
124 wks
→
Expected Death
~133 wks
→
With Treatment
~145 wks

Mice expected to live 9 weeks more lived 18-21 weeks instead. That's 109% longer remaining lifespan.

If This Were a Human...

Starting Age
80
→
Expected Death
85
→
With Treatment
95+

An 80-year-old expected to live 5 more years would instead live 10+ more years - and in better health.

The Mouse-Human Conversion

The mice were 124 weeks old - equivalent to humans in their early 80s.

At that age, mice normally have about 9-10 weeks left to live. After treatment, they lived 18-21 additional weeks. That's the 109% figure - more than double their expected remaining life.

Not Just More Years - Better Years

The treated mice didn't just survive longer in poor health. They became physically younger - more active, better frailty scores, moving around like younger mice.

In human terms: imagine an 80-year-old with the energy and mobility of a 60-year-old.

The Science

Study: Macip et al., February 2024

Journal: Cellular Reprogramming

Method: OSK gene therapy (Oct4, Sox2, Klf4)

PubMed: 38381405