The Essential Longevity Supplement Stack
Your Quick-Start Guide to Science-Backed Anti-Aging Supplements
LONGEVITY FUTURES
2025 Edition
Quick Start
What You'll Learn
NAD+ Boosters
- The foundation of any longevity stack
Senolytics
- Clear out "zombie cells" that cause aging
Mitochondrial Support
- Boost your cellular energy
Essential Vitamins
- The basics everyone needs
Sirtuin Activators
- Activate your "longevity genes"
Ready-Made Stacks
- Copy-paste protocols by budget
How to Use This Guide:
Each supplement has a quick-info box with dosage, timing, and our top product pick with a direct link.
Chapter 1
NAD+ Boosters
Why NAD+ Matters
NAD+ is essential for energy, DNA repair & longevity genes
Levels drop 50% by age 60
Low NAD+ = fatigue, brain fog, accelerated aging
Restoring NAD+ is step #1 for longevity
NMN
ESSENTIAL
Dose
250-500mg/day
When
Morning
Results
2-4 weeks
Best For
Maximum NAD+ boost
Direct NAD+ precursor (1 step to NAD+)
Dr. David Sinclair takes 1g daily
Boosts energy, focus, and recovery
Our Pick
ProHealth NMN Pro 300mg - $59.95
View on Amazon
*Affiliate link
NR (Nicotinamide Riboside)
MOST RESEARCHED
Dose
300mg/day
When
Morning
Results
2-4 weeks
Best For
Proven safety
30+ human clinical trials
FDA safety notification
Excellent for beginners
Our Pick
Tru Niagen 300mg - $52.99
View on Amazon
*Affiliate link
NMN vs NR?
Both work. NR has more research. NMN may be more potent. Start with either - you can't go wrong.
Chapter 2
Senolytics
What Are Zombie Cells?
"Senescent" cells stop working but won't die
They release toxins that damage healthy cells
Clearing 30% of them extends lifespan 25% in studies
Senolytics = supplements that kill zombie cells
Fisetin
MOST POTENT
Dose
100-500mg/day
When
With fatty meal
Protocol
Daily or 2-day cycles
Found In
Strawberries
Mayo Clinic: most potent natural senolytic
Also supports brain health
Powerful antioxidant
Our Pick
Renue by Science Lipo Fisetin - $47.95
View on Amazon
*Affiliate link
Quercetin
SYNERGY
Dose
500-1000mg/day
When
With meals
Best With
Fisetin
Found In
Onions, apples
Boosts fisetin's effects
Anti-inflammatory
Supports immune function
Our Pick
Thorne Quercetin Phytosome - $32.00
View on Amazon
*Affiliate link
Chapter 3
Mitochondrial Support
Your Cellular Powerhouses
Mitochondria make 90% of your energy
They decline with age = fatigue, weakness
Supporting them = more energy, better aging
CoQ10
ESSENTIAL
Dose
100-200mg/day
Best Form
Ubiquinol
When
With fatty meal
Must For
Statin users
Essential for energy production
Powerful antioxidant
Supports heart health
Our Pick
NOW CoQ10 100mg - $25.00
View on Amazon
*Affiliate link
Creatine
UNDERRATED
Dose
5g/day
Form
Monohydrate
When
Any time
Bonus
Brain benefits
Not just for athletes!
Preserves muscle with aging
Supports brain function
One of the safest supplements
Our Pick
NOW Foods Creatine Monohydrate 2.2lb - $36.38
View on Amazon
*Affiliate link
Chapter 4
Essential Vitamins & Minerals
The Foundation
No fancy supplement works without the basics
Most people are deficient in these
Start here before adding advanced supplements
Vitamin D3 + K2
FOUNDATIONAL
Dose
5000 IU D3 + 100mcg K2
Target
40-60 ng/mL blood level
When
With fatty meal
Why K2
Directs calcium to bones
Most people are deficient
Supports immune system
Essential for bones
K2 protects arteries
Our Pick
NOW Mega D-3 & MK-7 - $18.00
View on Amazon
*Affiliate link
Magnesium L-Threonate
BRAIN
Dose
144mg elemental Mg
When
Evening (helps sleep)
Why This Form
Crosses blood-brain barrier
Bonus
Better sleep
Only form proven to raise brain magnesium
Supports memory & focus
Improves sleep quality
Reduces stress
Our Pick
Thorne Magnesium Bisglycinate - $28.00
View on Amazon
*Affiliate link
Omega-3 Fish Oil
ANTI-INFLAMMATORY
Dose
2g EPA+DHA/day
Form
Triglyceride (not ethyl ester)
When
With meals
Quality
IFOS certified
Fights "inflammaging"
Supports heart & brain
Most people don't get enough
Our Pick
NOW Omega-3 Fish Oil - $18.00
View on Amazon
*Affiliate link
Chapter 5
Sirtuin Activators
Your Longevity Genes
Sirtuins = proteins that protect against aging
They need NAD+ as fuel (Chapter 1)
These supplements turn them "on"
Resveratrol
SIRTUIN ACTIVATOR
Dose
500-1000mg/day
Form
Trans-resveratrol
When
Morning with fat (yogurt)
Pair With
NMN or NR
Activates SIRT1 "longevity gene"
Dr. Sinclair: 1g/day with yogurt
Mimics calorie restriction benefits
Works best WITH NAD+ boosters
Our Pick
Thorne ResveraCel - $60.00
View on Amazon
*Affiliate link
Spermidine
AUTOPHAGY
Dose
1-2mg/day
Source
Wheat germ extract
Key Benefit
Cellular cleanup
Food Sources
Aged cheese, natto
Triggers autophagy (cellular cleanup)
Linked to longevity in humans
Mimics fasting benefits
Our Pick
Double Wood Spermidine - $29.95
View on Amazon
*Affiliate link
Chapter 6
Ready-Made Stacks
Copy These Protocols
BEGINNER STACK (~$75/month)
Vitamin D3 + K2
5000 IU + 100mcg
Omega-3 Fish Oil
2g
Magnesium L-Threonate
144mg
Creatine
5g
INTERMEDIATE STACK (~$150/month)
Everything above PLUS:
Tru Niagen (NR)
300mg
Fisetin
100mg
CoQ10
100mg
ADVANCED STACK (~$250/month)
Everything above PLUS:
NMN
500mg
Resveratrol
500mg
Quercetin
500mg
Spermidine
1mg
Daily Schedule
Morning
Midday
Evening
NMN/NR
Resveratrol
Vitamin D3+K2
Omega-3
Creatine
CoQ10
Magnesium
Fisetin
Quercetin
Start Slow:
Add one supplement at a time. Wait 1-2 weeks before adding another. Always consult your doctor first.
Quick Reference
All Products
NAD+ Boosters
ProHealth NMN Pro 300mg
- $59.95
Tru Niagen NR 300mg
- $52.99
Thorne ResveraCel
- $60.00
Senolytics
Renue by Science Lipo Fisetin
- $47.95
Thorne Quercetin Phytosome
- $32.00
Mitochondrial
NOW CoQ10 100mg
- $25.00
NOW Foods Creatine Monohydrate 2.2lb
- $36.38
Vitamins & Minerals
NOW Mega D-3 & MK-7
- $18.00
Thorne Magnesium Bisglycinate
- $28.00
NOW Omega-3 Fish Oil
- $18.00
Sirtuin Activators
Thorne ResveraCel
- $60.00
Double Wood Spermidine
- $29.95