Nickel Basics: Absorption, Interactions, and Who May Benefit

# Nickel Basics: Absorption, Interactions, and Who May Benefit

## Summary

Definition:Nickel is a trace transition metal found throughout the environment and present in many foods.Context:In biology it appears mainly as nickel ions and is essential for some microbes and plants; its clear essential role in humans is not firmly established. Primary roles:Nickel is involved in certain enzymatic reactions in lower organisms and may influence iron metabolism and some cellular signaling pathways in humans.Practical impact:Animal studies link nickel to effects on hemoglobin, bone, and glucose regulation; in humans the evidence for a required nutrient role is limited but suggestive.

## Benefits

Absorption:Dietary nickel absorption is generally low, typically under 10% when eaten with food.Factors:Absorption increases when nickel is ingested in water or on an empty stomach.Elimination:Nickel is rapidly excreted, mainly in urine, and does not strongly accumulate in most tissues.

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