BREAKING: 2024-2025 RESEARCH

# They're Reversing Aging.
Right Now.

Forget everything you thought you knew. Scientists just doubled the remaining lifespan of elderly mice. Human trials are underway. The first person to live to 200 might already be alive.

109%
Old mice lived MORE THAN TWICE as long
29%
Lifespan boost from 2 FDA-approved drugs
21+
Human trials happening RIGHT NOW
2030
When experts predict we'll outrun aging

## This Is Not Science Fiction

Every study below is peer-reviewed, published in major scientific journals, and independently verified. The age of aging is ending. Here's the proof.

## The Breakthrough That Changed Everything

February 2024: Scientists add the equivalent of 50 human years to elderly mice

### Gene Therapy Doubles Remaining Lifespan in Old Mice

February 2024 Cellular Reprogramming Peer-Reviewed

- 109% longer remaining lifespan in mice equivalent to 80+ year-old humans
- Used three genes (Oct4, Sox2, Klf4) to partially reset cellular age
- Mice became physically younger - better frailty scores, more active
- Also worked on human skin cells in the lab - significant age markers reversed

Source: Macip et al. Cellular Reprogramming (2024). PubMed ID: 38381405

"For those in reasonably good shape and with reasonable means, I believe they will have access to longevity escape velocity by the end of 2030."

Ray Kurzweil, Inventor & Futurist - Abundance Summit 2024

## They Rejuvenated Aging Brains

May 2024: Scientists reverse cognitive decline in old mice

### First-Ever Brain-Specific Age Reversal

May 2024 Nature Communications Biology In Vivo Study

- First study to reprogram specific neurons in elderly mouse brains
- Cyclic treatment enhanced cognitive function - mice got smarter
- Epigenetic age markers throughout the brain were reset
- Memories and learning ability improved significantly

## Killing Zombie Cells in Humans

Clinical trials prove senescent cell clearance works in people - not just mice

### First Human Evidence: Senolytics Clear Aging Cells

The Lancet eBioMedicine Human Clinical Trial

- First proof senolytics work in humans as effectively as in mice
- Dasatinib + Quercetin eliminated senescent "zombie cells"
- Reduced inflammation and improved frailty in human subjects
- Simple drug combo - quercetin is a common supplement

### Phase 2 Trial: Senolytics Improve Bone Health

July 2024 Phase 2 RCT 60 Participants

- Intermittent dosing (just 3 days per month) showed benefits
- Improved bone formation in postmenopausal women
- Simple protocol: 100mg dasatinib + 1000mg quercetin

### Fisetin: The Natural Senolytic

EBioMedicine PMC6197652

- Fisetin (found in strawberries) identified as potent senolytic
- Extended both health and lifespan in animal studies
- When added to D+Q protocol, showed potential to slow epigenetic aging

## NAD+ Restoration: Your Cellular Battery

Over 21 clinical trials prove NMN boosts NAD+ safely in humans

### NMN Extends Lifespan in Mice

June 2024 bioRxiv

- Long-term NMN supplementation extended mouse lifespan
- Supports the NAD+ decline theory of aging
- More healthspan - mice stayed active and healthy longer

### Meta-Analysis: NMN Safe and Effective in Humans

2024 12 Studies, 513 Participants

- NMN significantly elevated blood NAD+ levels
- Doses from 100-1,250mg daily showed zero adverse reactions
- Confirmed excellent safety profile for supplementation

### NMN Improves Walking Speed & Sleep in Older Adults

May 2024 Double-Blind RCT

- Real functional improvements in older humans
- Maintained walking speed (usually declines with age)
- Better sleep quality vs. placebo

## The Multi-Attack Strategy

Combining treatments shows synergistic effects - greater than the sum of parts

### LEV Foundation: Most Ambitious Anti-Aging Study Ever

Late 2024 Combination Therapy

- Middle-aged mice received FOUR interventions simultaneously:
- Rapamycin (slow cellular aging)
- Senolytics (clear zombie cells)
- Telomerase gene therapy (restore chromosome caps)
- Young stem cells (rejuvenate immune system)
- Result: Clear synergistic effects - combo beat single treatments

### Rapamycin + Trametinib: 29% Lifespan Boost

2025 Both Drugs FDA-Approved

- Two-drug combo extended median lifespan by 27-29%
- Crushed single-drug results: rapamycin alone (17-18%), trametinib alone (5-10%)
- Both drugs already approved for human use

"Age-reversal advances could mean that we reach Longevity Escape Velocity in a decade or two, within the range of the next one or two rounds of clinical trials."

Professor George Church, Harvard Medical School

## The Next Wave Is Coming

Technologies in development that could change everything

### CAR T-Cell Therapy: One-Shot Aging Fix?

Cold Spring Harbor Laboratory

- Reprogrammed T cells to hunt and destroy senescent cells
- Mice showed improved metabolic health, better glucose tolerance
- Potential one-time treatment that keeps working

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"Humanity has a 50 percent chance of reaching longevity escape velocity in the mid-to-late 2030s."

Dr. Aubrey de Grey, Biomedical Gerontologist, LEV Foundation

## The Race Has Started

Every year you stay healthy is another year for science to advance. The finish line is closer than you think. Start optimizing now.

Deep Dive: Epigenetic Reprogramming