Published by Paul Thompson |
Fact-checked against peer-reviewed sources | Updated March 2026

# Tretinoin: The Gold Standard

The strongest retinoid - prescription only, but worth it

What is Tretinoin? It's pure retinoic acid - the active form of vitamin A. Unlike retinol which has to convert in your skin, tretinoin works immediately. That's why it's stronger and faster.

### Why Tretinoin Is Different

OTC retinols have to convert to retinoic acid in your skin - a slow process. Tretinoin IS retinoic acid. No conversion needed. That's why:

- Faster results - See changes in weeks, not months
- Stronger effects - More collagen production, faster cell turnover
- Proven by decades of research - More studies than any other anti-aging ingredient
- Treats acne AND aging - Originally made for acne, now used for both

### Brand Names You'll See

- Retin-A - The original. Cream or gel formula.
- Renova - Specifically for anti-aging. More moisturizing base.
- Tretinoin (generic) - Same thing, lower price. Works just as well.
- Altreno - Newer lotion formula. Gentler on skin.

They all contain the same active ingredient - just different formulations.

### Strengths Available

- 0.025% - Lowest. Good starting point for sensitive skin.
- 0.05% - Most common. Good balance of results and tolerability.
- 0.1% - Strongest. For experienced users only.

Most dermatologists start you at 0.025% or 0.05% and work up if needed.

#### Important: Prescription Required

Tretinoin requires a prescription in most countries. You'll need to see a dermatologist or use a telehealth service. Don't buy from unregulated sources - you won't know what you're getting.

### How to Get Tretinoin

- Dermatologist - Best option. They'll assess your skin and prescribe the right strength.
- Telehealth - Services like Curology, Apostrophe, or Nurx offer online consultations and prescriptions.
- Your GP - Some general practitioners will prescribe it too.

Tell them you want it for anti-aging or acne (whichever applies). It's a common prescription.

### Not Ready for Prescription?

If tretinoin sounds too intense, start with OTC retinol first. Build up your tolerance, then consider prescription strength later. Many people get great results with retinol alone.

## Start Your Retinoid Journey

Check out our OTC retinol recommendations

Back to Retinoid Guide