ANTI-AGING HUB

# Science of Anti-Aging

Your body ages because of specific biological processes. Target those processes, and you can slow - even reverse - the clock. Welcome to evidence-based longevity.

8
Key Compounds
109%
Lifespan Extension (Mice)
21+
Human Trials Active

## Why We Age

Aging isn't random decay. It's a collection of specific biological processes that can be targeted and modified.

### The Hallmarks of Aging

Scientists have identified nine fundamental processes that drive aging. Target these, and you target aging itself:

- Genomic instability - DNA damage accumulates over time
- Telomere attrition - Chromosome caps shorten with each division
- Epigenetic alterations - Gene regulation patterns drift with age
- Loss of proteostasis - Protein quality control fails
- Mitochondrial dysfunction - Cellular power plants decline
- Cellular senescence - "Zombie cells" accumulate and cause inflammation
- Stem cell exhaustion - Regenerative capacity diminishes
- Altered intercellular communication - Cells miscommunicate

"Aging is a disease, and that disease is treatable."

Dr. David Sinclair, Harvard Medical School

## The Key Anti-Aging Compounds

These evidence-based compounds target the fundamental mechanisms of aging

NMN

### Nicotinamide Mononucleotide

The #1 NAD+ precursor. Restores cellular energy and activates longevity genes.

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NR

### Nicotinamide Riboside

Alternative NAD+ booster with excellent bioavailability and safety profile.

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RSV

### Resveratrol

Sirtuin activator that mimics caloric restriction benefits.

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FIS

### Fisetin

The most potent natural senolytic - clears zombie cells from your body.

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QRC

### Quercetin

Senolytic flavonoid that works synergistically with fisetin and dasatinib.

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SPD

### Spermidine

Autophagy activator found in high concentrations in centenarian populations.

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RAP

### Rapamycin

mTOR inhibitor with the most robust lifespan extension data in mammals.

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MET

### Metformin

Diabetes drug showing remarkable anti-aging effects. TAME trial underway.

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## Cellular Rejuvenation

The most exciting frontier: actually reversing cellular age, not just slowing it

### Epigenetic Reprogramming

In 2024, scientists achieved 109% lifespan extension in elderly mice using partial cellular reprogramming. The mice didn't just live longer - they became physically younger.

- OSK gene therapy resets cellular age without losing cell identity
- Epigenetic clocks showed actual age reversal
- Works on human cells in the lab
- Human trials expected within 5 years

### Senolytics: Killing Zombie Cells

Senescent "zombie cells" accumulate with age, secreting inflammatory signals that age surrounding tissue. Senolytics selectively destroy these cells.

- Dasatinib + Quercetin proven effective in humans
- Fisetin shows potent senolytic activity
- Intermittent dosing (3 days/month) shows benefits
- Multiple human trials now underway

### NAD+ Restoration

NAD+ levels decline 50% by middle age. This molecule is essential for cellular energy, DNA repair, and sirtuin activation.

- NMN and NR effectively boost NAD+ in humans
- 21+ clinical trials confirm safety and efficacy
- Improved walking speed, sleep quality in older adults
- Foundation of most longevity protocols

## The Future Is Closer Than You Think

We're not waiting decades anymore. The anti-aging revolution is happening now.

### What's Coming

- 2025-2027: First human trials of partial reprogramming for eyes and skin
- 2027-2030: Broader tissue applications, combination therapies
- 2030+: Potential systemic rejuvenation treatments

"For those in reasonably good shape and with reasonable means, I believe they will have access to longevity escape velocity by the end of 2030."

Ray Kurzweil, Inventor & Futurist

### The Bridge Strategy

You don't need to wait for gene therapy. The goal is to stay healthy long enough for each next breakthrough. Every year you maintain your health is another year for science to advance.

- Optimize your current biology with available interventions
- Stack multiple approaches for synergistic effects
- Monitor biomarkers to track biological age
- Stay informed on emerging research

## Start Your Anti-Aging Journey

The science is clear. The compounds are available. The only question is: are you ready to take control of how you age?

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