Longevity Futures — Evidence-Based Supplement Reviews | Written by Health Researchers
Comparisons

# Fisetin vs Creatine Monohydrate: Which One Should You Actually Take?

Published March 25, 2026 • Longevity Futures Research Team

## The Big Question

If you're building a longevity supplement stack, chances are you've come across both Fisetin and Creatine Monohydrate. They're both popular, both backed by research, and both promise to support healthy aging. So which one deserves your money?

Let's break it down honestly.

## Fisetin: What It Does

Emerging senolytic compound found in strawberries. Research shows it may be the most potent natural senolytic, clearing damaged zombie cells.

Key benefits: Senolytic, Neuroprotection, Anti-inflammatory, Anti-aging, Brain health

Our top pick: ProHealth Fisetin Pro 150mg — $29.95 (9.2/10)

## Creatine Monohydrate: What It Does

The most researched supplement in history. Supports muscle, brain, and cellular energy. Emerging longevity benefits beyond fitness.

Key benefits: Muscle strength, Brain function, Cellular energy, Recovery, Bone density

Our top pick: Thorne Creatine — $32.00 (9.5/10)

## Head to Head

Factor | Fisetin | Creatine Monohydrate
--- | --- | ---
Primary benefit | Senolytic | Muscle strength
Top product price | $29.95 | $32.00
Our rating | 9.2/10 | 9.5/10

## The Verdict

Here's the honest answer: they do different things. Fisetin excels at Senolytic while Creatine Monohydrate shines for Muscle strength. If you can only pick one, choose based on your biggest priority. If your budget allows, taking both as part of a complete stack is the ideal move.

ProHealth Fisetin Pro 150mg — $29.95 | 9.2/10
Check Price on Amazon →

For the full detailed comparison, visit our supplement comparison hub.

Not sure what your body needs most? Take the How Long Will You Live? quiz for personalised recommendations.

← Back to Blog | Home