Published by Paul Thompson |
Fact-checked against peer-reviewed sources | Updated March 2026

## Why a Longevity Stack?

No single supplement can address every aspect of aging. A well-designed stack targets multiple biological pathways simultaneously: NAD+ production, inflammation control, nutrient optimization, mitochondrial support, gut health, and immune defense.

This stack was designed to be practical, affordable, and evidence-based. Each supplement earns its place with strong clinical data and synergistic benefits when combined.

Daily Protocol: Take NMN and Creatine in the morning with breakfast. Omega-3 and Vitamin D with your largest meal (fat improves absorption). Magnesium and Probiotics in the evening before bed.

## The Complete Longevity Stack

### 1 NMN

The foundation of any longevity stack. NMN replenishes NAD+ levels that decline with age, supporting DNA repair, cellular energy, and metabolic function.

ProHealth NMN Pro 500mg Editor's Choice
Price: $44.95 Serving: 500mg per capsule
★★★★☆ 9.4/10

Pharmaceutical-grade NMN with third-party testing. The gold standard for NMN supplementation.

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### 2 Omega-3

Essential fatty acids your body cannot produce. EPA fights inflammation while DHA supports brain structure and function. Non-negotiable for longevity.

Thorne Super EPA Editor's Choice
Price: $32.00 Serving: 425mg EPA, 270mg DHA
★★★★☆ 9.5/10

Pharmaceutical-grade fish oil. IFOS 5-star certified for purity. No fishy aftertaste.

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### 3 Magnesium

Involved in 300+ enzymatic reactions and most adults are deficient. Critical for sleep quality, stress management, heart rhythm, and muscle recovery.

NOW Magnesium Glycinate Best for Sleep
Price: $16.99 Serving: 200mg per serving
★★★★☆ 9.4/10

Glycinate form is the most bioavailable and gentle on the stomach. Best choice for sleep and relaxation.

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### 4 Vitamin D3

The sunshine vitamin that up to 42% of adults lack. Essential for immune function, bone density, mood regulation, and increasingly linked to longevity.

NOW Vitamin D3 5000 IU Editor's Choice
Price: $11.99 Serving: 5000 IU per softgel
★★★★☆ 9.3/10

Optimal daily dose for most adults. Olive oil base for absorption. Incredible value.

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### 5 Creatine Monohydrate

Far more than a fitness supplement. Emerging research shows creatine supports brain energy, bone density, and cellular function in aging adults.

Thorne Creatine Editor's Choice
Price: $32.00 Serving: 5g per scoop
★★★★☆ 9.5/10

NSF Certified for Sport. Micronized for easy mixing. Thorne's pharmaceutical-grade purity.

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### 6 Probiotics

Gut health is the foundation of whole-body health. A diverse microbiome supports immune function, mental clarity, nutrient absorption, and skin health.

Physician's Choice 60 Billion CFU Editor's Choice
Price: $21.95 Serving: 60 billion CFU, 10 strains
★★★★☆ 9.3/10

High-potency multi-strain formula with prebiotic fiber. Shelf-stable, no refrigeration needed.

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## How We Built This Stack

Our criteria: Each supplement in this stack was chosen for three reasons: (1) strong clinical evidence for longevity or healthspan benefits, (2) addresses a common deficiency or age-related decline, and (3) works synergistically with the other supplements in the stack.

## Estimated Monthly Cost

Based on our top picks, this complete longevity stack costs approximately $130–$160 per month. That breaks down to about $4–$5 per day for a comprehensive anti-aging and health optimization protocol.

## Buying Guide

#### Third-Party Testing

Look for supplements tested by independent labs (NSF, USP, IFOS, or ConsumerLab) for purity and potency verification.

#### Bioavailable Forms

Not all supplement forms are equal. Phytosome, liposomal, and chelated forms typically offer superior absorption.

#### Dosage Transparency

Avoid proprietary blends. The label should clearly state exact amounts of each active ingredient per serving.

#### Brand Reputation

Stick with brands that have a track record of quality manufacturing, transparent sourcing, and published lab results.

### Related Questions

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