Published by Paul Thompson |
Fact-checked against peer-reviewed sources | Updated March 2026

# The Essential Longevity Supplement Stack

Your Quick-Start Guide to Science-Backed Anti-Aging Supplements

LONGEVITY FUTURES
2025 Edition
Quick Start

## What You'll Learn

- NAD+ Boosters - The foundation of any longevity stack
- Senolytics - Clear out "zombie cells" that cause aging
- Mitochondrial Support - Boost your cellular energy
- Essential Vitamins - The basics everyone needs
- Sirtuin Activators - Activate your "longevity genes"
- Ready-Made Stacks - Copy-paste protocols by budget

How to Use This Guide: Each supplement has a quick-info box with dosage, timing, and our top product pick with a direct link.
Chapter 1

## NAD+ Boosters

### Why NAD+ Matters

- NAD+ is essential for energy, DNA repair & longevity genes
- Levels drop 50% by age 60
- Low NAD+ = fatigue, brain fog, accelerated aging
- Restoring NAD+ is step #1 for longevity

#### NMN ESSENTIAL

Dose 250-500mg/day
When Morning
Results 2-4 weeks
Best For Maximum NAD+ boost

- Direct NAD+ precursor (1 step to NAD+)
- Dr. David Sinclair takes 1g daily
- Boosts energy, focus, and recovery

Our Pick
ProHealth NMN Pro 300mg - $59.95
View on Amazon *Affiliate link

#### NR (Nicotinamide Riboside) MOST RESEARCHED

Dose 300mg/day
When Morning
Results 2-4 weeks
Best For Proven safety

- 30+ human clinical trials
- FDA safety notification
- Excellent for beginners

Our Pick
Tru Niagen 300mg - $52.99
View on Amazon *Affiliate link
NMN vs NR? Both work. NR has more research. NMN may be more potent. Start with either - you can't go wrong.
Chapter 2

## Senolytics

### What Are Zombie Cells?

- "Senescent" cells stop working but won't die
- They release toxins that damage healthy cells
- Clearing 30% of them extends lifespan 25% in studies
- Senolytics = supplements that kill zombie cells

#### Fisetin MOST POTENT

Dose 100-500mg/day
When With fatty meal
Protocol Daily or 2-day cycles
Found In Strawberries

- Mayo Clinic: most potent natural senolytic
- Also supports brain health
- Powerful antioxidant

Our Pick
Renue by Science Lipo Fisetin - $47.95
View on Amazon *Affiliate link

#### Quercetin SYNERGY

Dose 500-1000mg/day
When With meals
Best With Fisetin
Found In Onions, apples

- Boosts fisetin's effects
- Anti-inflammatory
- Supports immune function

Our Pick
Thorne Quercetin Phytosome - $32.00
View on Amazon *Affiliate link
Chapter 3

## Mitochondrial Support

### Your Cellular Powerhouses

- Mitochondria make 90% of your energy
- They decline with age = fatigue, weakness
- Supporting them = more energy, better aging

#### CoQ10 ESSENTIAL

Dose 100-200mg/day
Best Form Ubiquinol
When With fatty meal
Must For Statin users

- Essential for energy production
- Powerful antioxidant
- Supports heart health

Our Pick
NOW CoQ10 100mg - $25.00
View on Amazon *Affiliate link

#### Creatine UNDERRATED

Dose 5g/day
Form Monohydrate
When Any time
Bonus Brain benefits

- Not just for athletes!
- Preserves muscle with aging
- Supports brain function
- One of the safest supplements

Our Pick
NOW Foods Creatine Monohydrate 2.2lb - $36.38
View on Amazon *Affiliate link
Chapter 4

## Essential Vitamins & Minerals

### The Foundation

- No fancy supplement works without the basics
- Most people are deficient in these
- Start here before adding advanced supplements

#### Vitamin D3 + K2 FOUNDATIONAL

Dose 5000 IU D3 + 100mcg K2
Target 40-60 ng/mL blood level
When With fatty meal
Why K2 Directs calcium to bones

- Most people are deficient
- Supports immune system
- Essential for bones
- K2 protects arteries

Our Pick
NOW Mega D-3 & MK-7 - $18.00
View on Amazon *Affiliate link

#### Magnesium L-Threonate BRAIN

Dose 144mg elemental Mg
When Evening (helps sleep)
Why This Form Crosses blood-brain barrier
Bonus Better sleep

- Only form proven to raise brain magnesium
- Supports memory & focus
- Improves sleep quality
- Reduces stress

Our Pick
Thorne Magnesium Bisglycinate - $28.00
View on Amazon *Affiliate link

#### Omega-3 Fish Oil ANTI-INFLAMMATORY

Dose 2g EPA+DHA/day
Form Triglyceride (not ethyl ester)
When With meals
Quality IFOS certified

- Fights "inflammaging"
- Supports heart & brain
- Most people don't get enough

Our Pick
NOW Omega-3 Fish Oil - $18.00
View on Amazon *Affiliate link
Chapter 5

## Sirtuin Activators

### Your Longevity Genes

- Sirtuins = proteins that protect against aging
- They need NAD+ as fuel (Chapter 1)
- These supplements turn them "on"

#### Resveratrol SIRTUIN ACTIVATOR

Dose 500-1000mg/day
Form Trans-resveratrol
When Morning with fat (yogurt)
Pair With NMN or NR

- Activates SIRT1 "longevity gene"
- Dr. Sinclair: 1g/day with yogurt
- Mimics calorie restriction benefits
- Works best WITH NAD+ boosters

Our Pick
Thorne ResveraCel - $60.00
View on Amazon *Affiliate link

#### Spermidine AUTOPHAGY

Dose 1-2mg/day
Source Wheat germ extract
Key Benefit Cellular cleanup
Food Sources Aged cheese, natto

- Triggers autophagy (cellular cleanup)
- Linked to longevity in humans
- Mimics fasting benefits

Our Pick
Double Wood Spermidine - $29.95
View on Amazon *Affiliate link
Chapter 6

## Ready-Made Stacks

### Copy These Protocols

#### BEGINNER STACK (~$75/month)

- Vitamin D3 + K2 5000 IU + 100mcg
- Omega-3 Fish Oil 2g
- Magnesium L-Threonate 144mg
- Creatine 5g

#### INTERMEDIATE STACK (~$150/month)

- Everything above PLUS:
- Tru Niagen (NR) 300mg
- Fisetin 100mg
- CoQ10 100mg

#### ADVANCED STACK (~$250/month)

- Everything above PLUS:
- NMN 500mg
- Resveratrol 500mg
- Quercetin 500mg
- Spermidine 1mg

### Daily Schedule

Morning | Midday | Evening
--- | --- | ---
NMN/NR Resveratrol Vitamin D3+K2 Omega-3 | Creatine CoQ10 | Magnesium Fisetin Quercetin

Start Slow: Add one supplement at a time. Wait 1-2 weeks before adding another. Always consult your doctor first.
Quick Reference

## All Products

### NAD+ Boosters

- ProHealth NMN Pro 300mg - $59.95
- Tru Niagen NR 300mg - $52.99
- Thorne ResveraCel - $60.00

### Senolytics

- Renue by Science Lipo Fisetin - $47.95
- Thorne Quercetin Phytosome - $32.00

### Mitochondrial

- NOW CoQ10 100mg - $25.00
- NOW Foods Creatine Monohydrate 2.2lb - $36.38

### Vitamins & Minerals

- NOW Mega D-3 & MK-7 - $18.00
- Thorne Magnesium Bisglycinate - $28.00
- NOW Omega-3 Fish Oil - $18.00

### Sirtuin Activators

- Thorne ResveraCel - $60.00
- Double Wood Spermidine - $29.95