Published by Paul Thompson |
Fact-checked against peer-reviewed sources | Updated March 2026

## Why These 6 Supplements?

Aging is driven by multiple biological mechanisms: NAD+ decline, mitochondrial dysfunction, cellular senescence, collagen degradation, chronic inflammation, and oxidative stress. The most effective anti-aging protocol targets all of these pathways simultaneously.

We selected the top product from each of six key anti-aging categories, giving you a comprehensive toolkit for biological age reduction.

## The Best Anti-Aging Supplements — Ranked

### NMN — NAD+ production, Cellular energy, DNA repair

NAD+ precursor that supports cellular energy, DNA repair, and longevity. One of the most researched anti-aging compounds.

1ProHealth NMN Pro 500mg
Editor's Choice
Price: $44.95 Serving: 500mg per capsule
★★★★☆ 9.4/10

Pharmaceutical-grade NMN with third-party testing. The gold standard for NMN supplementation.

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### Resveratrol — Sirtuin activation, Heart health, Anti-inflammatory

Powerful polyphenol found in red grapes. Activates sirtuins, the longevity genes. Anti-inflammatory and cardioprotective.

2ProHealth Trans-Resveratrol 1000mg
Editor's Choice
Price: $39.95 Serving: 1000mg per serving
★★★★☆ 9.3/10

High-potency trans-resveratrol. The bioactive form that research supports. Third-party tested.

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### CoQ10 — Mitochondrial energy, Heart health, Antioxidant

Essential for mitochondrial energy production. Natural levels decline with age. Critical for heart health and cellular energy.

3NOW CoQ10 100mg
Best Value
Price: $14.99 Serving: 100mg per softgel
★★★★☆ 9.2/10

Pharmaceutical-grade CoQ10 from a trusted brand. Excellent absorption. Unbeatable price per mg.

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### Collagen — Skin elasticity, Joint support, Hair growth

The most abundant protein in the body. Supports skin elasticity, joint health, hair, and nails. Production declines 1% per year after age 25.

4Vital Proteins Collagen Peptides
Editor's Choice
Price: $25.99 Serving: 20g per serving
★★★★☆ 9.5/10

Type I & III with Hyaluronic Acid and Vitamin C. Dissolves easily. 100K+ positive reviews.

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### Omega-3 — Heart health, Brain function, Anti-inflammatory

Essential fatty acids critical for brain, heart, and joint health. Most people are deficient. EPA reduces inflammation, DHA supports brain function.

5Thorne Super EPA
Editor's Choice
Price: $32.00 Serving: 425mg EPA, 270mg DHA
★★★★☆ 9.5/10

Pharmaceutical-grade fish oil. IFOS 5-star certified for purity. No fishy aftertaste.

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### Fisetin — Senolytic, Neuroprotection, Anti-inflammatory

Emerging senolytic compound found in strawberries. Research shows it may be the most potent natural senolytic, clearing damaged zombie cells.

6ProHealth Fisetin Pro 150mg
Editor's Choice
Price: $29.95 Serving: 150mg per capsule
★★★★☆ 9.2/10

Bioavailable fisetin from a trusted longevity brand. Third-party tested for purity.

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## How We Tested

Our methodology: We evaluated hundreds of supplements across six anti-aging categories. Each pick was selected based on clinical evidence, ingredient quality, bioavailable forms, third-party testing, brand reputation, and value. Only the top scorer in each category made this list.

## What to Look For

#### Third-Party Testing

Look for supplements tested by independent labs (NSF, USP, IFOS, or ConsumerLab) for purity and potency verification.

#### Bioavailable Forms

Not all supplement forms are equal. Phytosome, liposomal, and chelated forms typically offer superior absorption.

#### Dosage Transparency

Avoid proprietary blends. The label should clearly state exact amounts of each active ingredient per serving.

#### Brand Reputation

Stick with brands that have a track record of quality manufacturing, transparent sourcing, and published lab results.

### Related Questions

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