Published by Paul Thompson |
Fact-checked against peer-reviewed sources | Updated March 2026

## Side-by-Side Comparison

| Quercetin | Fisetin
--- | --- | ---
Category | Polyphenols & Senolytics | Polyphenols & Senolytics
Description | Powerful senolytic flavonoid that helps clear damaged cells. Anti-inflammatory, antihistamine, and immune-supporting properties. | Emerging senolytic compound found in strawberries. Research shows it may be the most potent natural senolytic, clearing damaged zombie cells.
Key Benefits | Senolytic, Anti-inflammatory, Immune support, Antihistamine, Heart health | Senolytic, Neuroprotection, Anti-inflammatory, Anti-aging, Brain health
Best For | Anti-aging, Inflammation, Immune, Allergies | Anti-aging, Brain, Longevity
Top Pick Price | $28.00 | $29.95

## Best Quercetin Products

Our top-rated Quercetin supplements based on purity, dosage, third-party testing, and value.

1Thorne Quercetin Phytosome
Best Absorption
Price: $28.00 Serving: 250mg phytosome
★★★★☆ 9.4/10

Phytosome form is 20x more bioavailable than standard quercetin. Thorne pharmaceutical grade.

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2NOW Quercetin with Bromelain
Best Value
Price: $16.99 Serving: 500mg quercetin + 100mg bromelain
★★★★☆ 9.0/10

Quercetin paired with bromelain for enhanced absorption. Great anti-inflammatory combo.

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3Life Extension Bio-Quercetin
Longevity Pick
Price: $15.00 Serving: 150mg bio-enhanced
★★★★☆ 9.1/10

Bio-enhanced quercetin with 62x better absorption. From the longevity supplement leaders.

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## Best Fisetin Products

Our top-rated Fisetin supplements based on purity, dosage, third-party testing, and value.

1ProHealth Fisetin Pro 150mg
Editor's Choice
Price: $29.95 Serving: 150mg per capsule
★★★★☆ 9.2/10

Bioavailable fisetin from a trusted longevity brand. Third-party tested for purity.

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2Double Wood Fisetin 100mg
Best Value
Price: $15.95 Serving: 100mg per capsule
★★★★☆ 8.8/10

Affordable fisetin at a solid dose. Good entry point for senolytic supplementation.

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3Life Extension Bio-Fisetin
Best Absorption
Price: $18.00 Serving: Bio-enhanced fisetin
★★★★☆ 9.0/10

Bio-enhanced form for improved absorption. From the pioneers in longevity science.

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## Which Should You Choose?

### Quercetin vs Fisetin — The Verdict

Both Quercetin and Fisetin are valuable supplements with distinct mechanisms of action. The best choice depends on your individual health goals.

For anti-aging: Quercetin has strong research backing for cellular rejuvenation and longevity support.

For brain health: Fisetin shows promise for neuroprotection and cognitive support.

For beginners: Start with whichever aligns more closely with your primary health goal. Both are well-researched and generally safe for most adults.

For advanced users: Many longevity researchers take both. They work through different mechanisms and can complement each other in a well-designed stack.

Pro Tip: Many longevity researchers combine both Quercetin and Fisetin in their daily protocols. If budget allows, using both may provide complementary benefits.

### Related Questions

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