Published by Paul Thompson |
Fact-checked against peer-reviewed sources | Updated March 2026

# Best Anti-Aging Supplements for Men

Support healthy aging at the cellular level with these science-backed longevity supplements.

Aging accelerates after 50 due to declining NAD+ levels, increased oxidative stress, and cellular damage. These supplements target the root causes of aging to help you stay vital longer.

## Recommended Supplements

Best Overall
TRU NIAGEN NAD+ 300mg
Patented NAD+ booster for brain function, anti-aging & cell regeneration. #1 Best Seller.
$49.00
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Best Value
ProHealth Resveratrol 1000mg
Pure Trans-Resveratrol + Quercetin, Red Wine & Green Tea Extract. 60 Capsules.
$31.08
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Best for Heart
Nordic Naturals ProOmega 2000-D
1125mg EPA, 875mg DHA + Vitamin D3. Heart, brain & immune health. 60 softgels.
$48.75
View on Amazon

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### Anti-Aging Lifestyle Essentials

- Intermittent fasting - Activates autophagy (cellular cleanup)
- Resistance training - Preserves muscle and bone density
- Quality sleep - When repair and regeneration happen
- Manage stress - Chronic stress accelerates aging

## FAQ

#### What's the most important anti-aging supplement?

NAD+ boosters (NMN or NR) are among the most promising based on current research. They support cellular energy, DNA repair, and activate longevity pathways that decline with age.

#### Do anti-aging supplements actually work?

Many have solid research backing specific benefits - Omega-3s for heart health, NMN for cellular energy, Resveratrol for cardiovascular protection. They work best combined with healthy lifestyle habits.

#### When should I start taking these supplements?

Foundation supplements (Omega-3s, Vitamin D) benefit men in their 30s-40s. More targeted longevity supplements like NMN become increasingly relevant after 40-50 as cellular function declines.