Published by Paul Thompson |
Fact-checked against peer-reviewed sources | Updated March 2026

## Side-by-Side Comparison

| Omega-3 | Krill Oil
--- | --- | ---
Category | Essential Fatty Acids | Supplement
Description | Essential fatty acids critical for brain, heart, and joint health. Most people are deficient. EPA reduces inflammation, DHA supports brain function. | A popular supplement in the longevity space. Research continues to explore its full benefits.
Key Benefits | Heart health, Brain function, Anti-inflammatory, Joint support, Mood | Various health benefits
Best For | Heart, Brain, Joints, Inflammation | General wellness

## Best Omega-3 Products

Our top-rated Omega-3 supplements based on purity, dosage, third-party testing, and value.

1 Thorne Super EPA
Editor's Choice
Price: $32.00 Serving: 425mg EPA, 270mg DHA
★★★★☆ 9.5/10

Pharmaceutical-grade fish oil. IFOS 5-star certified for purity. No fishy aftertaste.

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2 Nordic Naturals Ultimate Omega
Best Dose
Price: $27.95 Serving: 650mg EPA, 450mg DHA
★★★★☆ 9.3/10

High-potency triglyceride form. Award-winning purity. Lemon flavored — no fish burps.

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3 NOW Ultra Omega-3
Best Value
Price: $15.99 Serving: 500mg EPA, 250mg DHA
★★★★☆ 8.8/10

Molecularly distilled for purity. Great EPA/DHA ratio at an unbeatable price. Enteric coated.

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## Which Should You Choose?

### Omega-3 vs Krill Oil — The Verdict

Both Omega-3 and Krill Oil are valuable supplements with distinct mechanisms of action. The best choice depends on your individual health goals.

For heart health: Omega-3 has demonstrated cardiovascular benefits in research studies.

For beginners: Start with whichever aligns more closely with your primary health goal. Both are well-researched and generally safe for most adults.

For advanced users: Many longevity researchers take both. They work through different mechanisms and can complement each other in a well-designed stack.

Pro Tip: Many longevity researchers combine both Omega-3 and Krill Oil in their daily protocols. If budget allows, using both may provide complementary benefits.

### Related Questions

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