Published by Paul Thompson |
Fact-checked against peer-reviewed sources | Updated March 2026

## Side-by-Side Comparison

| Resveratrol | Fisetin
--- | --- | ---
Category | Polyphenols & Senolytics | Polyphenols & Senolytics
Description | Powerful polyphenol found in red grapes. Activates sirtuins, the longevity genes. Anti-inflammatory and cardioprotective. | Emerging senolytic compound found in strawberries. Research shows it may be the most potent natural senolytic, clearing damaged zombie cells.
Key Benefits | Sirtuin activation, Heart health, Anti-inflammatory, Anti-aging, Brain protection | Senolytic, Neuroprotection, Anti-inflammatory, Anti-aging, Brain health
Best For | Anti-aging, Heart, Brain | Anti-aging, Brain, Longevity
Top Pick Price | $39.95 | $29.95

## Best Resveratrol Products

Our top-rated Resveratrol supplements based on purity, dosage, third-party testing, and value.

1 ProHealth Trans-Resveratrol 1000mg
Editor's Choice
Price: $39.95 Serving: 1000mg per serving
★★★★☆ 9.3/10

High-potency trans-resveratrol. The bioactive form that research supports. Third-party tested.

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2 Thorne ResveraCel
Best Stack
Price: $58.00 Serving: 150mg resveratrol + NR
★★★★☆ 9.1/10

Combines resveratrol with nicotinamide riboside for dual sirtuin and NAD+ activation.

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3 NOW Resveratrol 200mg
Best Value
Price: $18.99 Serving: 200mg per capsule
★★★★☆ 8.5/10

Affordable resveratrol from a trusted brand. Good entry-level option for daily use.

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## Best Fisetin Products

Our top-rated Fisetin supplements based on purity, dosage, third-party testing, and value.

1 ProHealth Fisetin Pro 150mg
Editor's Choice
Price: $29.95 Serving: 150mg per capsule
★★★★☆ 9.2/10

Bioavailable fisetin from a trusted longevity brand. Third-party tested for purity.

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2 Double Wood Fisetin 100mg
Best Value
Price: $15.95 Serving: 100mg per capsule
★★★★☆ 8.8/10

Affordable fisetin at a solid dose. Good entry point for senolytic supplementation.

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3 Life Extension Bio-Fisetin
Best Absorption
Price: $18.00 Serving: Bio-enhanced fisetin
★★★★☆ 9.0/10

Bio-enhanced form for improved absorption. From the pioneers in longevity science.

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## Which Should You Choose?

### Resveratrol vs Fisetin — The Verdict

Both Resveratrol and Fisetin are valuable supplements with distinct mechanisms of action. The best choice depends on your individual health goals.

For anti-aging: Resveratrol has strong research backing for cellular rejuvenation and longevity support.

For heart health: Resveratrol has demonstrated cardiovascular benefits in research studies.

For brain health: Fisetin shows promise for neuroprotection and cognitive support.

For beginners: Start with whichever aligns more closely with your primary health goal. Both are well-researched and generally safe for most adults.

For advanced users: Many longevity researchers take both. They work through different mechanisms and can complement each other in a well-designed stack.

Pro Tip: Many longevity researchers combine both Resveratrol and Fisetin in their daily protocols. If budget allows, using both may provide complementary benefits.

### Related Questions

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